Critical care medicine
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Critical care medicine · Aug 2006
WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock.
To determine the effect of an estrogen receptor-beta selective agent in experimental models of systemic infection and sepsis. ⋯ These results indicate that oral administration of WAY-202196 preserved gastrointestinal barrier function and improved outcome in experimental models of systemic infection and inflammation. WAY-202196 and similar agents may prove useful clinically as a novel treatment strategy for the treatment or prevention of severe sepsis.