Critical care medicine
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Critical care medicine · Mar 2007
Plasma gelsolin is a marker and therapeutic agent in animal sepsis.
Plasma gelsolin is a circulating actin-binding protein that serves a protective role against tissue injuries. Depletion of plasma gelsolin in systemic inflammation may contribute to adverse outcomes. We examined the role of plasma gelsolin in animal models of sepsis. ⋯ We propose that circulation of particulate actin is a marker for sepsis-induced cell injury, that plasma gelsolin has a crucial protective role in sepsis, and that gelsolin replacement represents a potential therapy for this common lethal condition.
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Critical care medicine · Mar 2007
Editorial Comment Comparative StudyMorbidly obese patients with acute respiratory failure: don't reach for the endotracheal tube yet!