Critical care medicine
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Critical care medicine · Jan 2008
Comparative StudyModification of acute cardiovascular homeostatic responses to hemorrhage following mild to moderate traumatic brain injury.
The cardiovascular homeostatic responses to hemorrhage are coordinated in the central nervous system. Coincidental brain injury, which is present in 64% of trauma patients, could impair these responses. Our objective was to test the hypothesis that mild to moderate traumatic brain injury alters cardiovascular reflex responses to acute hemorrhage. ⋯ Acute mild and moderate traumatic brain injury disrupts cardiovascular homeostatic responses to extracranial hemorrhage; this disruption is graded according to the severity of traumatic brain injury. Severe disruption is associated with an increase in early mortality.
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Critical care medicine · Jan 2008
Mortality risk and length of stay associated with self-inflicted burn injury: evidence from a national sample of 30,382 adult patients.
Existing studies report contradictory findings regarding characteristics and outcomes of patients admitted with self-inflicted burn injuries. The objective of this study was to report demographic and medical characteristics of patients admitted to burn centers with self-inflicted burn injuries and to assess mortality risk and length of stay compared with patients whose injuries were not self-inflicted. ⋯ Compared with patients with similar demographic, health, and injury characteristics whose injuries are not self-inflicted, patients with self-inflicted burn injuries are not at greater risk of mortality and do not require longer durations of intensive care or total hospitalization.
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More than a million patients are admitted annually to U. S. hospitals with acute heart failure. Multicentered hospital-based registries and surveys in the United States and Europe have shown that the typical patient is >70 yrs of age, with a history of heart failure, coronary artery disease, and hypertension. ⋯ The risk of subsequent hospital readmission is high. The elderly, those with comorbidities, and those with cardiogenic shock or renal failure do particularly badly. Better treatment by those with expertise in the management of this syndrome and good follow-up care are likely to improve the outcome for this large group of patients.
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Critical care medicine · Jan 2008
Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats.
Alveolar fibrin deposition is a hallmark of pneumonia. It has been proposed that natural inhibitors of coagulation, including activated protein C, antithrombin, and tissue factor pathway inhibitor, exert lung-protective effects via anticoagulant and possibly anti-inflammatory pathways. We investigated the role of these natural anticoagulants in Streptococcus pneumoniae pneumonia. ⋯ Anticoagulant treatment attenuates pulmonary coagulopathy during S. pneumoniae pneumonia. Antithrombin seems to exert significant lung-protective effects in pneumococcal pneumonia in rats.
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Critical care medicine · Jan 2008
Effect of hypertonic saline concentration on cerebral and visceral organ water in an uninjured rodent model.
Hypertonic saline has been shown to be an effective osmotic agent to reduce brain water and hence brain volume and intracranial pressure. A direct correlation between dose and effect has been demonstrated, but no studies have compared the effects of different concentrations of the same osmotic load of hypertonic saline over time. We compared the effects of different tonicity of infused hypertonic saline on cerebral, lung, and small bowel water extraction over time under controlled conditions. ⋯ Hypertonic saline is effective in reducing organ water content in a setting of preserved blood-brain barrier but is not as effective in visceral organs. At equiosmotic doses of hypertonic saline, concentration plays no substantial role in altering serum osmolarity but appears to benefit duration of action. At very high concentrations, such as 23.4% NaCl, additional water extraction is also manifested. At such high concentration of NaCl, tonicity, indeed, matters, especially in water shifts across the blood-brain barrier.