Critical care medicine
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Critical care medicine · Mar 2009
Randomized Controlled Trial Multicenter Study Comparative StudyInteraction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock.
Vasopressin and corticosteroids are often added to support cardiovascular dysfunction in patients who have septic shock that is nonresponsive to fluid resuscitation and norepinephrine infusion. However, it is unknown whether vasopressin treatment interacts with corticosteroid treatment. ⋯ There is a statistically significant interaction between vasopressin and corticosteroids. The combination of low-dose vasopressin and corticosteroids was associated with decreased mortality and organ dysfunction compared with norepinephrine and corticosteroids.