Critical care medicine
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Critical care medicine · May 2009
Comparative StudyPancreatic stone protein is highly increased during posttraumatic sepsis and activates neutrophil granulocytes.
The level of pancreatic stone protein/regenerating protein (PSP/reg), a secretory protein produced in the pancreas, increases dramatically during pancreatic disease. However, after stress (e.g., anesthesia), PSP/reg levels are increased transiently in animals without pancreatic injury. Therefore, we aimed to determine whether PSP/reg is an acute-phase protein after nonpancreatic trauma. ⋯ We conclude that PSP/reg is up-regulated in blood after trauma, and the PSP/reg level is related to the severity of inflammation. Furthermore, PSP/reg binds to and activates neutrophils. Therefore, PSP/reg might be an acute-phase protein that could serve as a marker for posttraumatic complications.
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Critical care medicine · May 2009
Comparative StudyFailed interleukin-6 signal transduction in murine sepsis: attenuation of hepatic glycoprotein 130 phosphorylation.
Sepsis impairs the activation of the interleukin (IL)-6 dependent transcription factor signal transducer and activator of transcription (STAT)-3. However, the molecular basis for depressed functionality has not been characterized. In this study, we test the hypothesis that altered signal transduction results from a change in the activation state of one or more of the components of the intracellular IL-6-linked pathway. ⋯ Impaired gp130 phosphorylation may be responsible for IL-6 hyporesponsiveness during sepsis.
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Critical care medicine · May 2009
Editorial CommentAcute respiratory distress syndrome and the Art of War.