Critical care medicine
-
Critical care medicine · Jan 2012
Comparative StudyEfficacy of linezolid compared to vancomycin in an experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated pigs.
To assess the efficacy of linezolid compared with vancomycin in an experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus (MRSA) in ventilated pigs. ⋯ In this animal model of MRSA pneumonia, linezolid showed a better efficacy than vancomycin showed because of a better pharmacokinetics/pharmacodynamics index.
-
Critical care medicine · Jan 2012
Arginine reduces bacterial invasion in rats with head injury: an in vivo evaluation by bioluminescence.
The benefit of arginine in intensive care unit patients with severe sepsis is still controversial. An excessive supply of arginine could lead to an overproduction of nitric oxide and could be responsible for septic shock and multiorgan failure. However, this claim is not supported by any experimental or clinical data. We set out to determine whether an enteral supply of arginine would modulate bacterial invasion in rats with head injury. ⋯ Arginine was not responsible for mortality in rats with head injury with infectious complications and reduced the intensity of bacterial invasion.