Critical care medicine
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Critical care medicine · May 2013
Comparative StudyHydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice.
Hydrogen inhalation was neuroprotective in several brain injury models. Its mechanisms are believed to be related to antioxidative stress. We investigated the potential neurovascular protective effect of hydrogen inhalation especially effect on mast cell activation in a mouse model of intracerebral hemorrhage. ⋯ Activation of mast cells following intracerebral hemorrhage contributed to increase of blood-brain barrier permeability and brain edema. Hydrogen inhalation preserved blood-brain barrier disruption by prevention of mast cell activation after intracerebral hemorrhage.
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Critical care medicine · May 2013
Editorial CommentResearch during pandemics: has the horse left the barn?
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Critical care medicine · May 2013
Comparative StudyHexamethonium reverses the lethal cardiopulmonary damages in a rat model of brainstem lesions mimicking fatal enterovirus 71 encephalitis.
Among enterovirus 71 infections, brainstem encephalitis progressing abruptly to cardiac dysfunction and pulmonary edema causes rapid death within several hours. However, no currently known early indicators and treatments can monitor or prevent the unexpectedly fulminant course. We investigate the possible mechanisms and treatment of fatal enterovirus 71 infections to prevent the abrupt progression to cardiac dysfunction and pulmonary edema by using an animal model. ⋯ Early hexamethonium treatment attenuates acute excessive release of catecholamines to prevent cardiac dysfunction and pulmonary edema for increasing survival rate.
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Critical care medicine · May 2013
Comparative StudyChanges in brain tissue oxygenation after treatment of diffuse traumatic brain injury by erythropoietin.
To investigate the effects of recombinant human erythropoietin on brain oxygenation in a model of diffuse traumatic brain injury. ⋯ Our findings indicate that brain hypoxia can be related to microcirculatory derangements and cell edema without evidence of brain ischemia. These changes were reversed with post-traumatic administration of recombinant human erythropoietin, thus offering new perspectives in the use of this drug in brain injury.