Critical care medicine
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Critical care medicine · Mar 2015
Editorial CommentInverse ratio ventilation: back to the future?*.
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Critical care medicine · Mar 2015
Randomized Controlled TrialPatients' Perspectives of Enrollment in Research Without Consent: The Patients' Experiences in Emergency Research-Progesterone for the Treatment of Traumatic Brain Injury Study.
Research in acute illness often requires an exception from informed consent. Few studies have assessed the views of patients enrolled in exception from informed consent trials. This study was designed to assess the views of patients and their surrogates of exception from informed consent enrollment within the context of a randomized, placebo-controlled trial of an investigational agent for traumatic brain injury. ⋯ Acceptance of exception from informed consent in this placebo-controlled trial of an investigational agent was high and exceeded acceptance among community consultation participants. Exception from informed consent enrollment appears generally consistent with patients' preferences.