Critical care medicine
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Critical care medicine · Feb 2021
Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C.
Oxidative stress appears to initiate organ failure in sepsis, justifying treatment with antioxidants such as vitamin C at megadoses. We have therefore investigated the safety and efficacy of megadose sodium ascorbate in sepsis. ⋯ IV megadose sodium ascorbate reversed the pathophysiological and behavioral responses to Gram-negative sepsis without adverse side effects. Clinical studies are required to determine if such a dose has similar benefits in septic patients.
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Critical care medicine · Feb 2021
Historical ArticleCo-Evolutions of Pediatric and Adult Critical Care.