Critical care medicine
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Critical care medicine · May 2022
Editorial CommentFalling for It: Of Falls, Families, and Delirium.
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Critical care medicine · May 2022
Randomized Controlled Trial Multicenter StudyEvaluating Vitamin C in Septic Shock: A Randomized Controlled Trial of Vitamin C Monotherapy.
To determine whether IV vitamin C therapy reduces 28-day mortality in patients with septic shock. ⋯ Vitamin C monotherapy failed to significantly reduce mortality in septic shock patients as hypothesized. Our findings do not support its routine clinical use for this purpose.
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Critical care medicine · May 2022
Randomized Controlled Trial Multicenter StudyEarly Neuromuscular Blockade in Moderate-to-Severe Pediatric Acute Respiratory Distress Syndrome.
The use of neuromuscular blocking agents (NMBAs) in pediatric acute respiratory distress syndrome (PARDS) is common but unsupported by efficacy data. We sought to compare the outcomes between patients with moderate-to-severe PARDS receiving continuous NMBA during the first 48 hours of endotracheal intubation (early NMBA) and those without. ⋯ Early NMBA use was associated with a longer duration of MV. This propensity score analysis underscores the need for a randomized controlled trial in pediatrics.