Critical care medicine
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Critical care medicine · Apr 2003
Effects of exogenous surfactant supplementation and partial liquid ventilation on acute lung injury induced by wood smoke inhalation in newborn piglets.
To investigate the beneficial effects of exogenous surfactant supplementation (ESS) and partial liquid ventilation (PLV) in treating acute lung injury induced by wood smoke inhalation. ⋯ In a newborn piglet model of smoke inhalation injury, PLV or ESS improved oxygenation. PLV compared favorably with ESS in its greater improvements in lung compliance and lung pathology. However, the combined therapy of ESS and PLV was not clearly superior to PLV alone during the observation period.
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Critical care medicine · Apr 2003
Alteration in epithelial permeability and ion transport in a mouse model of total parenteral nutrition.
To investigate the effects of total parenteral nutrition administration on intestinal ion transport and intestinal epithelial permeability. Additionally, to assess the role of interferon-gamma on the total parenteral nutrition-induced loss of epithelial barrier function. ⋯ Total parenteral nutrition has significant effects on intestinal epithelial physiology, stimulating ion secretion and reducing epithelial barrier function. Interferon-gamma appears to play an important role in the loss of the epithelial barrier function that is associated with total parenteral nutrition.
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Critical care medicine · Apr 2003
Comparative StudyComparison of polyacrylonitrile (AN69) and polysulphone membrane during hemofiltration in canine endotoxic shock.
This study was designed to compare the effects of continuous venovenous hemofiltration (CVVH) with two different membranes, polysulphone and polyacrylonitrile (AN69), on global and regional hemodynamics, plasma lactate, tumor necrosis factor-alpha levels, and plasma nitrite/nitrate during endotoxic shock in dogs. ⋯ In this acute endotoxic shock model, CVVH with the polyacrylonitrile membrane improved cardiac performance when compared with the polysulphone membrane. These effects could be caused by a more effective adsorption of inflammatory mediators other than tumor necrosis factor. Whether the polyacrylonitrile membrane should be preferred over the polysulphone membrane for CVVH in severe sepsis warrants further experimental and clinical study.