Critical care medicine
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Critical care medicine · Mar 2002
Randomized Controlled Trial Multicenter Study Clinical TrialDexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial.
To establish the safety of intravenous dexanabinol in severe head injury. ⋯ Dexanabinol was safe and well tolerated in severe head injury. The treated patients achieved significantly better intracranial pressure/cerebral perfusion pressure control without jeopardizing blood pressure. A trend toward faster and better neurologic outcome was also observed.
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Critical care medicine · Mar 2002
Randomized Controlled Trial Comparative Study Clinical TrialRandomized comparison of nasojejunal and nasogastric feeding in critically ill patients.
Critically ill patients often develop large gastric residual volumes during nasogastric feeding as a result of poor gastroduodenal motility. Nasojejunal feeding may decrease the severity of this complication. The aim of this study was to determine whether nasojejunal feeding improved tolerance of enteral nutrition by reducing gastric residual volumes. ⋯ Enteral nutrition delivered via a nasojejunal tube is associated with a significant reduction in gastric residual volume, a strong trend toward improved tolerance of enteral nutrition, and an extremely low requirement for parenteral nutrition.
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Critical care medicine · Mar 2002
Multicenter Study Clinical Trial Controlled Clinical TrialNew treatment of acute hypoxemic respiratory failure: noninvasive pressure support ventilation delivered by helmet--a pilot controlled trial.
To assess the efficacy of noninvasive pressure support ventilation (NPSV) using a new special helmet as first-line intervention to treat patients with hypoxemic acute respiratory failure (ARF), in comparison to NPSV using standard facial mask. ⋯ NPSV by helmet successfully treated hypoxemic ARF, with better tolerance and fewer complications than facial mask NPSV.
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Critical care medicine · Mar 2002
Multicenter Study Comparative StudyAcute severe asthma: differences in therapies and outcomes among pediatric intensive care units.
To determine differences in therapies and outcomes among pediatric intensive care units for patients with acute severe asthma. ⋯ We found that use of invasive interventions including mechanical ventilation and vascular monitoring varied greatly by institution. Centers with higher use of mechanical ventilation had longer median intensive care stay and hospital stays. Pediatric asthma management for acute severe asthma may be improved by clear elucidation of the institutional practices where fewer invasive interventions were used to achieve better outcomes.
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Critical care medicine · Mar 2002
Multicenter StudyRelationship between premortem and postmortem diagnosis in critically ill bone marrow transplantation patients.
To determine the relationship between the premortem and postmortem diagnosis in critically ill bone marrow transplantation patients Also, to evaluate the appropriateness of the reliance on clinical diagnosis for withdrawal of active treatment decision-making. ⋯ In the bone marrow transplantation population, there is significant concordance between clinical diagnosis and postmortem findings. Reliance on clinical diagnosis may be valid for withdrawal of active treatment decision-making in these patients.