Human psychopharmacology
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Human psychopharmacology · Jun 2009
Multicenter StudyFunctional magnetic resonance imagery (fMRI) in fibromyalgia and the response to milnacipran.
Functional imaging has been used to study response to pain in fibromyalgia patients. Functional magnetic resonance imagery (fMRI) which tracks local changes in blood flow has a higher spatial and temporal resolution than other techniques such as positron emission tomography (PET) or single-photon emission tomography (SPECT). fMRI studies in fibromyalgia patients suggest that similar levels of subjective pain result in similar central nervous system (CNS) activation in both fibromyalgia patients and controls. ⋯ The hypothesis that increased sensitivity to pain is due to decreased activity of the descending inhibitory pathways is supported by results with milnacipran. Fibromyalgia patients treated with the serotonin and noradrenaline reuptake inhibitor, milnacipran, exhibited a reduction in pain sensitivity and a parallel increase in activity in brain regions implicated in the descending pain inhibitory pathways compared to placebo-treated patients.
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Human psychopharmacology · Aug 2008
Randomized Controlled Trial Multicenter StudyEffects of warm-supplementing kidney yang (WSKY) capsule added on risperidone on cognition in chronic schizophrenic patients: a randomized, double-blind, placebo-controlled, multi-center clinical trial.
To evaluate the effects of warm-supplementing kidney yang (WSKY) capsule added on risperidone on cognition in chronic schizophrenic patients. ⋯ WSKY capsule added on risperidone may improve cognitive function, social function of the chronic schizophrenic patients, and the WSKY safely during treatment.
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Human psychopharmacology · Dec 2004
Letter Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialPost-treatment emergent adverse events in depressed patients following treatment with milnacipran and paroxetine.