Journal of Korean medical science
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J. Korean Med. Sci. · Apr 2023
Evaluation of Vancomycin TDM Strategies: Prediction and Prevention of Kidney Injuries Based on Vancomycin TDM Results.
The current guidelines for therapeutic drug monitoring (TDM) of vancomycin suggest a target 24-hour area under the curve (AUC0-24) of 400 to 600 mg*h/L for serious methicillin-resistant Staphylococcus aureus infections. In this study, the predictabilities of acute kidney injury (AKI) of various TDM target parameters, target levels, and sampling methods were evaluated in patients who underwent TDM from January 2020 to December 2020. ⋯ Among the AUC0-24 cutoff comparisons, the threshold value of 500 mg*h/L in the two sampling methods was statistically significant (P = 0.042) when evaluated for the predictability of AKI. Analysis by an receiver operating characteristic curve estimated an AUC0-24 cutoff value of 563.45 mg*h/L as a predictor of AKI, and was proposed as the upper limit of TDM target.
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J. Korean Med. Sci. · Apr 2023
Maternal Polycystic Ovary Syndrome and the Risk of Early Childhood Obesity in Female Offspring: A Nationwide Population-Based Study.
To investigate the relationship between polycystic ovary syndrome (PCOS) in Korean women and childhood growth and obesity of their offspring. ⋯ Maternal PCOS is independently associated with an increased incidence of childhood obesity in female offspring among Korean women. Women with PCOS should consider the risk of early childhood obesity in their daughters, even if they maintain a healthy weight themselves.
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J. Korean Med. Sci. · Apr 2023
Comparative Analysis of Central Asian Publication Activity Using SCImago Journal & Country Rank Data in 1996-2021.
Central Asian countries (CACs) are less visible in the global scientific environment, despite their solid scientific nature. The current article aimed to assess the publication productivity of CACs since 1996 using SCImago Journal & Country Rank (SJR). ⋯ Despite a rising number of articles, CACs are not at the forefront of scientific productivity in the Asiatic Region. Kazakhstan is the leading country in scientific productivity among CACs. Nonetheless, the increasing quantity of articles from CACs over the last ten years suggests that these countries have the infrastructure and human resources to enhance scientific research and production.