Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Apr 2017
Review Meta AnalysisSystematic review with meta-analysis: the efficacy and safety of CT-P13, a biosimilar of anti-tumour necrosis factor-α agent (infliximab), in inflammatory bowel diseases.
Biosimilars of anti-tumour necrosis factor (TNF)-α agents have now become clinically available for the treatment of inflammatory bowel diseases (IBD). ⋯ CT-P13 was associated with excellent clinical efficacy and safety profile, supporting its use in the treatment of IBD.
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Aliment. Pharmacol. Ther. · Jan 2017
Review Meta Analysis Comparative StudySystematic review with meta-analysis: comparative efficacy of immunosuppressants and biologics for reducing hospitalisation and surgery in Crohn's disease and ulcerative colitis.
Crohn's disease (CD) and ulcerative colitis (UC) have a progressive course leading to hospitalisation and surgery. The ability of existing therapies to alter disease course is not clearly defined. ⋯ In CD and UC, anti-TNF biologics are efficacious in reducing the odds of hospitalisation by half and surgery by 33-77%. Azathioprine and vedolizumab were not associated with a similar improvement, but robust conclusions may be limited due to paucity of RCTs.
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Aliment. Pharmacol. Ther. · Jun 2016
Review Meta AnalysisSystematic review with network meta-analysis: comparative effectiveness and safety of strategies for preventing NSAID-associated gastrointestinal toxicity.
Many strategies are used to prevent nonsteroidal anti-inflammatory drug (NSAID)-associated gastrointestinal toxicity, but the comparative effectiveness remains unclear. ⋯ The combination of selective COX-2 inhibitors plus PPIs provides the best gastrointestinal protection, followed by selective COX-2 inhibitors, and thirdly by nonselective NSAIDs plus PPIs.
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Aliment. Pharmacol. Ther. · Feb 2016
Review Meta AnalysisSystematic review with meta-analysis: long-term outcomes of faecal microbiota transplantation for Clostridium difficile infection.
Clostridium difficile infection is a major cause of nosocomial diarrhoea. ⋯ Faecal microbiota transplantation seems to be a highly effective and robust therapy for recurrent C. difficile infection. However, more quality studies, such as randomised controlled trials and cohort studies with control groups, are needed to confirm its long-term efficacy and safety.
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Aliment. Pharmacol. Ther. · Nov 2015
Review Meta AnalysisSystematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults.
The effects of probiotics are strain specific. The clinical effects of each strain need to be evaluated separately. ⋯ This meta-analysis shows that Lactobacillus rhamnosus GG is effective in preventing antibiotic-associated diarrhoea in children and adults treated with antibiotics for any reason. However, the quality of evidence is moderate to low.