Alimentary pharmacology & therapeutics
-
Aliment. Pharmacol. Ther. · Oct 2015
Review Meta AnalysisSystematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea.
Antibiotic-associated diarrhoea is a common complication of antibiotic use, but it can be prevented with administration of probiotics. ⋯ This meta-analysis confirms that S. boulardii is effective in reducing the risk of antibiotic-associated diarrhoea in children and adults.
-
Aliment. Pharmacol. Ther. · Sep 2015
Review Meta AnalysisSystematic review with meta-analysis: coffee consumption and the risk of gallstone disease.
Epidemiologic evidence on coffee consumption reducing the risk of gallstone disease has been contradictory. ⋯ This study suggests that coffee consumption is related to a significantly decreased risk of gallstone disease.
-
Aliment. Pharmacol. Ther. · Jun 2015
Review Meta AnalysisSystematic review and meta-analysis: opportunistic infections and malignancies during treatment with anti-integrin antibodies in inflammatory bowel disease.
Anti-integrin antibodies are effective therapies for Crohn's disease (CD) and ulcerative colitis (UC). However, these drugs carry theoretical risks of opportunistic infection and malignancy. ⋯ Absolute numbers of opportunistic infections were higher with anti-integrin antibodies, but this difference is not statistically significant. There was no increased risk of malignancy detected. Long-term data in large prospective cohorts are needed to further assess this issue.
-
Aliment. Pharmacol. Ther. · Apr 2015
Review Meta AnalysisSystematic review with network meta-analysis: the comparative effectiveness and safety of interventions in patients with overt hepatic encephalopathy.
Interventional treatment for overt hepatic encephalopathy (OHE), includes non-absorbable disaccharides, neomycin, rifaximin, L-ornithine-L-aspartate and branched chain amino acids (BCAA). However, the optimum regimen remains inconclusive. ⋯ L-ornithine-L-aspartate treatment may show a trend in superiority for clinical efficacy among standard interventions for OHE. Rifaximin shows the greatest reduction in blood ammonia concentration, and treatment with neomycin demonstrates a higher probability in causing adverse effects among the five compared interventions.
-
Aliment. Pharmacol. Ther. · Oct 2014
Review Meta AnalysisSystematic review with network meta-analysis: adjuvant therapy for resected biliary tract cancer.
Major adjuvant therapies for biliary tract cancer (BTC) include fluorouracil, gemcitabine and chemoradiation (CRT), but the optimum regimen remains inconclusive. ⋯ Chemotherapy with gemcitabine is the optimum adjuvant treatment with a balanced benefit-toxicity ratio for resected biliary tract cancer. Chemoradiation was more likely to cause toxic effects.