Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · May 2008
Meta AnalysisMeta-analysis: ertapenem for complicated intra-abdominal infections.
Ertapenem is a new member of the carbapenem class of antibiotics, with a favourable pharmacokinetic profile, but a narrower spectrum of antimicrobial activity, compared with older representatives of this class. ⋯ This meta-analysis provides additional evidence that ertapenem can be used as effectively and safely, as other recommended antimicrobial regimens, for the treatment of complicated intra-abdominal infections, particularly of mild-to-moderate severity.
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Aliment. Pharmacol. Ther. · Apr 2007
Review Meta AnalysisMeta-analysis: Lactobacillus GG for treating acute diarrhoea in children.
To review evidence for the effectiveness of Lactobacillus GG (LGG) in treating acute infectious diarrhoea in children. ⋯ The use of LGG is associated with moderate clinical benefits in the treatment of acute diarrhoea in children. These findings should be interpreted with caution due to the important methodological limitations and heterogeneity of most of the studies.
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Aliment. Pharmacol. Ther. · Mar 2007
Meta AnalysisMeta-analysis: randomized controlled trials of clindamycin/aminoglycoside vs. beta-lactam monotherapy for the treatment of intra-abdominal infections.
To compare the effectiveness and safety of clindamycin/aminoglycoside with broad-spectrum beta-lactam monotherapy in patients with intra-abdominal infections by performing a meta-analysis of randomized controlled trials (RCTs). ⋯ The results of our meta-analysis suggest that beta-lactams are more effective in the treatment of intra-abdominal infections compared with clindamycin/aminoglycoside.
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Aliment. Pharmacol. Ther. · Feb 2007
Meta AnalysisMeta-analysis: ondansetron for vomiting in acute gastroenteritis in children.
Vomiting is a common sympton in children with gastroenteritis, but its treatment remains controversial. ⋯ Despite some clinical benefits, there is insufficient evidence to recommend the routine use of ondansetron for vomiting during acute gastroenteritis in children.
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Aliment. Pharmacol. Ther. · Feb 2007
Meta AnalysisMeta-analysis: Saccharomyces boulardii for treating acute diarrhoea in children.
Saccharomyces boulardii is a non-pathogenic probiotic yeast considered useful against enteropathogens. ⋯ There exists a moderate clinical benefit of S. boulardii therapy in otherwise healthy infants and children with acute gastroenteritis, mainly a shorter duration of diarrhoea. However, these results should be interpreted with caution due to methodological limitations of the included studies.