Wiener medizinische Wochenschrift
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Wien Med Wochenschr · Jan 1996
Review[Sleep fragmentation as the cause of daytime sleepiness and reduced performance].
Studies in healthy young adults revealed that periodic arousals during the night result in increasing sleepiness as a function of the interval of time between arousals. When arousals are frequent, deficits similar to those seen after total sleep deprivation have been found. Observed decrements appear to be specifically related to EEG arousals and do not require complete awakening. In patients with fragmenting sleep disorders such as periodic leg movements and central sleep apnea, improved nocturnal sleep is related to increased alertness and daytime performance.
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Wien Med Wochenschr · Jan 1996
Review[Not all coughing is asthma--on differential bronchial asthma diagnosis in childhood].
Cough and wheezing are typical symptoms of asthma in childhood. But depending on age there are also other causes for the appearance of such complaints. A systematic approach to the differential diagnosis will clarify the situation in most of the patients.
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Wien Med Wochenschr · Jan 1996
[In vitro transformation of amniotic cells to muscle cells--background and outlook].
DNA analysis of peripheral blood leucocytes is routinely used to demonstrate mutations in the dystrophin gene in patients with Duchenne's muscular dystrophy. In approximately 35% of patients. DNA studies are not informative; in these patients immunochemical analysis of a muscle-biopsy specimen can determine whether dystrophin, the protein product of the gene for Duchenne's dystrophy, is absent. ⋯ After 6 weeks skeletal-muscle proteins could be detected in 10 amniocyte cultures. Cultures from fetuses with no family history of Duchenne's dystrophy expressed dystrophin, cultures from patients with Duchenne's dystrophy were dystrophin-deficient. Immunochemical analysis of dystrophin in genetically altered non-muscle cells may be applicable to the prenatal diagnosis of Duchenne's muscular dystrophy when conventional DNA analysis is not informative.
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Wien Med Wochenschr · Jan 1996
[Methodology and problems in home monitoring of children with sleep-related respiratory disorders--perspectives].
In a pilot study we interviewed parents of 100 formerly home monitored infants about problems during the monitoring period. The duration of home monitoring was between 1 and 48 months (median 15 months). 95% of the parents reported false alarms. 66% of the infants had real alarms, in 50% of the infants interventions were necessary. 3% of the infants had to be resuscitated. Only 47% of the parents felt safe in the practice of resuscitation even though all parents had been trained before. Perspectives of improvement of home monitoring are discussed.