Journal of veterinary internal medicine
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Dogs with hyperadrenocorticism are at risk of thromboembolic disease, which might be caused by an underlying hypercoagulable state. ⋯ Dogs with ADHAC have thrombelastographic evidence of hypercoagulability and remained hypercoagulable during treatment. AT deficiency does not appear to be involved in the pathogenesis of hypercoagulability in this population.
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J. Vet. Intern. Med. · Sep 2013
Prospectively recorded versus medical record-derived spinal cord injury scores in dogs with intervertebral disk herniation.
Validated spinal cord injury (SCI) scores have been established for veterinary species but are not uniformly used in practice. ⋯ Results showed that SCI scores recorded at the time of admission often do not agree with those retrospectively abstracted from medical records. Agreement was less when using the more complex TSCIS scale and therefore the MFS scale might be more appropriate for use in retrospective studies.
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J. Vet. Intern. Med. · May 2013
Hypercoagulability in dogs with protein-losing nephropathy as assessed by thromboelastography.
Dogs with protein-losing nephropathy (PLN) are at risk of thromboembolic disease, but the mechanism leading to hypercoagulability and the population of dogs at risk are unknown. ⋯ These results indicate that dogs with PLN have TEG values that demonstrate hypercoagulability compared with a control population but that antithrombin, SALB, or UPC cannot be used in isolation to predict this result. A comprehensive evaluation of the coagulation system in individual patients may be necessary to predict the point at which anti-thrombotic therapy is indicated.
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J. Vet. Intern. Med. · Mar 2013
Multicenter StudyRenin-Angiotensin-aldosterone system and hypothalamic-pituitary-adrenal axis in hospitalized newborn foals.
The renin-angiotensin-aldosterone system (RAAS) and hypothalamic-pituitary-adrenal axis (HPAA) and their interactions during illness and hypoperfusion are important to maintain organ function. HPAA dysfunction and relative adrenal insufficiency (RAI) are common in septic foals. Information is lacking on the RAAS and mineralocorticoid response in the context of RAI in newborn sick foals. ⋯ RAAS activation in critically ill foals is characterized by increased ANG-II and aldosterone concentrations. Inappropriately low cortisol and aldosterone concentrations defined as high ACTH/cortisol and ACTH/aldosterone ratios in septic foals suggest that RAI is not restricted to the zona fasciculata in critically ill newborn foals.
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J. Vet. Intern. Med. · Mar 2013
Comparative StudyDoppler and volumetric echocardiographic methods for cardiac output measurement in standing adult horses.
Cardiac output (CO) is not routinely measured in critically ill adult horses because of invasiveness of currently validated methods. Noninvasive CO monitoring would complement clinical assessment of hemodynamic status in adult horses. ⋯ The 4-chamber area-length, Simpson, bullet, and RVOT Doppler provided better agreement with lithium dilution than the other methods evaluated. These methods warrant further investigation for use in critically ill adult horses.