AIDS
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To assess the evidence that the association between educational attainment and risk of HIV infection is changing over time in sub-Saharan Africa. ⋯ HIV infections appear to be shifting towards higher prevalence among the least educated in sub-Saharan Africa, reversing previous patterns. Policy responses that ensure HIV-prevention measures reach all strata of society and increase education levels are urgently needed.
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To assess the evidence that the association between educational attainment and risk of HIV infection is changing over time in sub-Saharan Africa. ⋯ HIV infections appear to be shifting towards higher prevalence among the least educated in sub-Saharan Africa, reversing previous patterns. Policy responses that ensure HIV-prevention measures reach all strata of society and increase education levels are urgently needed.
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Review Multicenter Study
Risk factors for lactic acidosis and severe hyperlactataemia in HIV-1-infected adults exposed to antiretroviral therapy.
Severe hyperlactataemia and lactic acidosis are rare serious complications of antiretroviral therapy (ART). ⋯ Hyperlactataemia/lactic acidosis was associated with exposure to dideoxynucleosides, female gender, advanced immunosuppression and possibly ethnicity. This has important consequences for choice of ART in resource-limited settings. The association with shorter duration of exposure may support the hypothesis of susceptibility in a small proportion of patients.