Journal of clinical epidemiology
-
Review Comparative Study
Head-to-head randomized trials are mostly industry sponsored and almost always favor the industry sponsor.
To map the current status of head-to-head comparative randomized evidence and to assess whether funding may impact on trial design and results. ⋯ The literature of head-to-head RCTs is dominated by the industry. Industry-sponsored comparative assessments systematically yield favorable results for the sponsors, even more so when noninferiority designs are involved.