Journal of clinical epidemiology
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To examine whether the use of natural language processing (NLP) technology is effective in assisting rapid title and abstract screening when updating a systematic review. ⋯ NLP technology using the ensemble learning method may effectively assist in rapid literature screening when updating systematic reviews.
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This text builds on a conversation with Dr. Gordon Guyatt who provided guidance to trainees on interdisciplinary collaboration and work-life balance as part of a graduate-level biostatistics course in September 2020. The participants in the conversation comprised a group of clinicians, methodologists and biostatisticians, ranging from junior trainees to world-renowned established researchers. ⋯ As an invited guest, Dr. Guyatt shares his experiences after decades of leadership and successful international collaborations. He emphasizes the importance finding the right mentor, forming productive collaborations, developing self-awareness, and strategies for achieving a work-life balance.
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To present a structured approach for assessing stakeholder perceptions and implementing the approach in guideline development. ⋯ The FACE criteria propose a series of knowledge translation questions to guide the assessment of implementation for evidence-based guidelines. It is desirable for guideline developers to use a conceptual approach, such as FACE, to tailor implementation and inform end of guideline dissemination and knowledge translation activities.
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Comparing observed and expected distributions of categorical outcome variables in randomized controlled trials (RCTs) has been previously used to assess publication integrity. We applied this technique to withdrawals from RCTs. ⋯ Comparing the observed and expected distribution of trial withdrawals may be a useful technique when considering publication integrity of a body of RCTs.
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The Trials within Cohorts design aims to reduce recruitment difficulties and disappointment bias in pragmatic trials. On cohort enrollment, broad informed consent for randomization is asked, after which cohort participants can be randomized to interventions or serve as controls without further notification. We evaluated patients' recollection, understanding, and acceptance of broad consent in a clinical oncology setting. ⋯ Patients adequately remember giving broad consent for randomization shortly after cohort enrollment and after being offered an intervention, but recollection is lower in those never selected for interventions. Patients are acceptant of serving as control without further notifications.