Journal of clinical epidemiology
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N-of-1 trials can be aggregated to estimate population treatment effects using hierarchical Bayesian models. It is very important to report core items in hierarchical Bayesian analysis. In this study, we assessed reporting of items in hierarchical Bayesian analysis for aggregating N-of-1 trials to estimate population treatment effects. ⋯ Reporting of core items in hierarchical Bayesian analysis for aggregating N-of-1 trials to estimate population treatment effects is suboptimal. A PRISMA-like guidance on reviews of Bayesian N-of-1 trials may be required in the future.
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N-of-1 trials can be aggregated to estimate population treatment effects using hierarchical Bayesian models. It is very important to report core items in hierarchical Bayesian analysis. In this study, we assessed reporting of items in hierarchical Bayesian analysis for aggregating N-of-1 trials to estimate population treatment effects. ⋯ Reporting of core items in hierarchical Bayesian analysis for aggregating N-of-1 trials to estimate population treatment effects is suboptimal. A PRISMA-like guidance on reviews of Bayesian N-of-1 trials may be required in the future.
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Review
Appropriate statistical methods were infrequently used in cluster-randomized crossover trials.
To assess the design and statistical methods used in cluster-randomized crossover (CRXO) trials. ⋯ There is a need for improved application of appropriate analysis and sample size methods, and reporting, in CRXO trials.
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Review
Appropriate statistical methods were infrequently used in cluster-randomized crossover trials.
To assess the design and statistical methods used in cluster-randomized crossover (CRXO) trials. ⋯ There is a need for improved application of appropriate analysis and sample size methods, and reporting, in CRXO trials.
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To summarize the current gaps in human immunodeficiency virus (HIV) research evidence, describe the adequacy of reporting "implications for research," and map the number of studies that inform reviews with the prevalence of HIV for each country. ⋯ Knowledge gaps were identified for research in younger participants, over longer periods, using more pragmatic interventions, conducted in resource-limited settings and incorporating economic evaluations. Implications for research are not always reported according to the EPICOT+ format. Not all countries with a high prevalence of HIV are contributing sufficiently to HIV research.