Journal of neurotrauma
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Journal of neurotrauma · May 2021
The use of regression tree analysis for predicting the functional outcome following traumatic spinal cord injury.
Predicting the long-term functional outcome after traumatic spinal cord injury (TSCI) is needed to adapt medical strategies and plan an optimized rehabilitation. This study investigates the use of regression trees for the development of predictive models based on acute clinical and demographic predictors. This prospective study was performed on 172 patients hospitalized after TSCI. ⋯ Other important predictors were the ISS, age, neurological level, and delay before surgery. Regression trees offer promising performances for predicting the functional outcome after a TSCI. It could help to determine the number and type of predictors leading to a prediction model of the functional outcome that can be used clinically in the future.
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Journal of neurotrauma · May 2021
Protocol-specific effects of intermittent hypoxia preconditioning on phrenic motor plasticity in rats with chronic cervical spinal cord injury.
"Low-dose" acute intermittent hypoxia (AIH; 3-15 episodes/day) is emerging as a promising therapeutic strategy to improve motor function after incomplete cervical spinal cord injury (cSCI). Conversely, chronic "high-dose" intermittent hypoxia (CIH; > 80-100 episodes/day) elicits multi-system pathology and is a hallmark of sleep apnea, a condition highly prevalent in individuals with cSCI. Whereas daily AIH (dAIH) enhances phrenic motor plasticity in intact rats, it is abolished by CIH. ⋯ In contrast, unlike shorter protocols in intact rats, CIH28-2/2 did not abolish pLTF in chronic C2Hx. Mechanisms of differential responses to dAIH versus CIH are not yet known, particularly in the context of cSCI. Further, it remains unclear whether enhanced phrenic motor plasticity can improve breathing after cSCI.
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Journal of neurotrauma · May 2021
A TrkB Antibody Agonist Promotes Plasticity after Cervical Spinal Cord Injury in Adult Rats.
After spinal cord injury (SCI) in mammals, there is only limited repair and, consequently, only moderate recovery. One mechanism frequently discussed to be involved in this recovery is plasticity (i.e., adaptations in spared neuronal circuitries). In the current study, we tested the effect of an intrathecal application of the TrkB agonist antibody, 29D7, on plasticity after cervical SCI in adult rats. ⋯ The reaching behaviors of the paw ipsilateral to the side of severe injury to the cortico- and rubrospinal tract were not altered by the treatment. The present study suggests that 29D7 may be a potential candidate to promote plasticity and functional recovery, especially after moderate SCI. Future studies confirming these results, along with a potential combinatory therapy including rehabilitative training, will be needed to evaluate the clinical value of such a treatment.
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Journal of neurotrauma · May 2021
ReviewMeeting Proceedings for SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research.
The spinal cord injury (SCI) research community has experienced great advances in discovery research, technology development, and promising clinical interventions in the past decade. To build upon these advances and maximize the benefit to persons with SCI, the National Institutes of Health (NIH) hosted a conference February 12-13, 2019 titled "SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research." The purpose of the conference was to bring together a broad range of stakeholders, including researchers, clinicians and healthcare professionals, persons with SCI, industry partners, regulators, and funding agency representatives to break down existing communication silos. Invited speakers were asked to summarize the state of the science, assess areas of technological and community readiness, and build collaborations that could change the trajectory of research and clinical options for people with SCI. In this report, we summarize the state of the science in each of five key domains and identify the gaps in the scientific literature that need to be addressed to move the field forward.