Journal of clinical anesthesia
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Randomized Controlled Trial Comparative Study Clinical Trial
Pharmacodynamic effects of three doses of ORG 9426 used for endotracheal intubation in humans.
To determine the pharmacodynamic characteristics of three incremental doses of ORG 9426 used for endotracheal intubation in patients. ⋯ These findings warrant further clinical evaluation of ORG 9426 for induction and maintenance of muscle relaxation in humans.
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Randomized Controlled Trial Comparative Study Clinical Trial
Patient-controlled drug administration during local anesthesia: a comparison of midazolam, propofol, and alfentanil.
To evaluate the perioperative effects of alfentanil, midazolam, and propofol when administered using a patient-controlled analgesia (PCA) device during local anesthesia. ⋯ When self-administered as adjuvants during local anesthesia using a PCA delivery system, alfentanil, midazolam, and propofol were equally acceptable to patients. However, propofol and midazolam were associated with fewer perioperative complications than was alfentanil.
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Review Case Reports
Intraoral vascular malformation and airway management: a case report and review of the literature.
A patient with a large airway venous malformation underwent anesthesia for a tooth extraction. The procedure was uneventful until extubation, immediately after which complete airway obstruction resulted. After unsuccessful attempts to relieve the problem, the patient's trachea was reintubated. ⋯ Anesthesiologists must be concerned with any airway vascular abnormality. Most abnormalities involving the airway are either hemangiomas or venous malformations. The anesthesiologist must diagnose the problem correctly because even minor manipulation of a venous malformation may result in exsanguination, or the malformation may become engorged and compromise the airway.
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Randomized Controlled Trial Clinical Trial
Effect of low fresh gas flow rates on inspired gas composition in a circle absorber system.
To determine the effects of fresh gas flow on inspired gas composition during low-flow anesthesia. ⋯ The same initial period of denitrogenation is not adequate to denitrogenate the circle system in all cases. The lower the fresh gas flow, the longer the initial period of denitrogenation should be. Various levels of fresh gas flow for low-flow anesthesia have been suggested, but none guarantees adequate control of inspired gas composition unless flowmeters are continuously adjusted.
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To investigate whether hyperventilation significantly altered oxygen consumption in anesthetized and paralyzed patients undergoing surgery. ⋯ In anesthetized paralyzed patients, there is an increase in whole-body VO2 with hypocapnic alkalosis.