Journal of clinical anesthesia
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Comparative Study Clinical Trial Controlled Clinical Trial
Epidural administration of liposome-associated bupivacaine for the management of postsurgical pain: a first study.
To explore the influence of liposomes on the pharmacodynamic action of bupivacaine and to determine whether postsurgical analgesic advantages can be obtained from epidural delivery of liposomal bupivacaine compared with the current formulation. ⋯ The liposomal formulation of bupivacaine increased duration of analgesia without motor block or adverse side effects.
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Comparative Study
Predictive accuracy of midazolam in adult patients scheduled for coronary surgery.
To evaluate the predictive accuracy of midazolam during cardiac anesthesia so as to orient the selection of the most appropriate pharmacokinetic model for use in a computer-assisted continuous-infusion system. ⋯ Two of the 3 pharmacokinetic data sets of midazolam studied may be selected when using a computer-assisted infusion system in adult coronary patients.
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Historical Article
The role of anesthesiology in the health care system of The Netherlands.
With the initiation of regular anesthesia services in the Netherlands in 1947, anesthesiology has grown to a large and influential profession, including intensive care, resuscitation, pain therapy, and emergency medical care. Pre- and postgraduate training programs are formalized and compete with some of the best in the world. ⋯ Anesthesia is restricted to medical specialists, but with the permanent support of fully trained and qualified nurses. Anesthesia in the Netherlands is a "two person" job.
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Randomized Controlled Trial Comparative Study Clinical Trial
Bair hugger forced-air warming maintains normothermia more effectively than thermo-lite insulation.
To compare the ability of forced-air warming and reflective insulation to maintain intraoperative normothermia. ⋯ Reflective insulation was unable to maintain intraoperative normothermia during total hip arthroplasty. Active warming, such as that provided by forced air, was required to prevent hypothermia.
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Randomized Controlled Trial Comparative Study Clinical Trial
Continuous administration of fentanyl for postoperative pain: a comparison of the epidural, intravenous, and transdermal routes.
To evaluate the influence of the route of administration [epidural, intravenous (IV), or transdermal] on onset and quality of analgesia and to evaluate the pharmacokinetics of continuous administration of fentanyl. ⋯ The epidural, transdermal, and IV administration of identical doses of fentanyl given at a constant rate provided almost equivalent degrees of analgesia. But continuing epidural administration produced a steady rise in systemic fentanyl concentrations into the ventilatory-depressant range, affecting the hypoxemic regulation of breathing.