Journal of clinical anesthesia
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Randomized Controlled Trial Comparative Study Clinical Trial
Pharmacokinetics of intranasal alfentanil.
To determine the pharmacokinetics of intranasal and intravenous (IV) administrations of alfentanil in 10 healthy volunteers. ⋯ This pharmacokinetic study demonstrates a rapid rise in plasma concentrations, as well as a high bioavailability, following the intranasal administration of alfentanil.
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Randomized Controlled Trial Comparative Study Clinical Trial
Antiemetic efficacy of a droperidol-morphine combination in patient-controlled analgesia.
To evaluate the antiemetic effectiveness and side effects of adding low-dose droperidol to morphine delivered via a patient-controlled analgesia (PCA) device. ⋯ An intermittent intake of low-dose droperidol with morphine given via a PCA delivery system in two treatment groups gave evidence for a dose-response relation between the amount of droperidol added and the proportion of patients needing a rescue antiemetic. The same result applied to the proportion of patients having an emetic episode and the number of times a rescue antiemetic had to be administered. There was no evidence that the low dose of droperidol added to morphine delivered via a PCA device increased unwanted side effects.
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Randomized Controlled Trial Comparative Study Clinical Trial
Laryngeal mask airway: a more successful method of insertion.
To compare the ease of insertion of the laryngeal mask airway (LMA) by two methods. ⋯ Inserting the LMA with the cuff partially inflated is likely to be more successful than with the cuff fully deflated. When it is not possible to insert the LMA with the cuff fully deflated, partial inflation before insertion may result in correct placement.
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Randomized Controlled Trial Clinical Trial
Hypoxemia during outpatient gastrointestinal endoscopy: the effects of sedation and supplemental oxygen.
To compare the effects on oxygen saturation as measured by pulse oximetry (SpO2) and ECG changes of endoscopy alone, sedation followed by endoscopy, and sedation followed by endoscopy with supplemental oxygen (O2) during upper gastrointestinal (GI) endoscopy. ⋯ The use of hypnotic doses of benzodiazepines is the primary factor responsible for the reduced oxygenation seen during endoscopy. Neither the presence of the endoscope alone nor the use of midazolam with supplemental O2 caused a decreased oxygenation. This study also suggests that the routine use of benzodiazepines is unnecessary when the endoscopy is of short duration, and the endoscopist employs good topicalization of the oropharynx. In patients who require sedation for endoscopy, O2 administration prevents hypoxemia.
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Randomized Controlled Trial Clinical Trial
The efficacy of routine central venous monitoring in major head and neck surgery: a retrospective review.
To further define the efficacy of routine central venous catheter placement for major head and neck surgery from the standpoint of fluid and blood administration, and various other parameters of perioperative management. ⋯ The study raises doubt about the efficacy of routine central venous catheter placement as a necessary guide for fluid and blood administration for these procedures, or as a necessary adjunct for several other parameters of perioperative management. It suggests the need for a randomized, prospective evaluation.