Journal of clinical anesthesia
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Randomized Controlled Trial Comparative Study Clinical Trial
The efficacy of guanfacine in reducing perioperative hemodynamic changes and volatile anesthetic requirement.
To evaluate the efficacy of guanfacine, an alpha 2-adrenergic agonist, for attenuating hemodynamic changes associated with tracheal intubation or extubation, providing intraoperative hemodynamic stability, and reducing inhalation anesthetic requirement in patients undergoing gynecologic surgery. ⋯ Guanfacine 1 mg administered orally proved to be an effective premedicant for providing intraoperative hemodynamic stability, attenuating the increase in BP and HR associated with tracheal intubation and extubation, and reducing anesthetic requirements without increasing the incidence of perioperative complications.
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Randomized Controlled Trial Comparative Study Clinical Trial
Sevoflurane versus halothane for general anesthesia in pediatric patients: a comparative study of vital signs, induction, and emergence.
To compare vital signs and the speed of induction and emergence with sevoflurane versus halothane in pediatric patients. ⋯ Induction of and emergence from anesthesia was faster with sevoflurane than halothane. Airway complications were low in both groups. Vital signs were more stable with sevoflurane during induction through intubation, and were comparable during maintenance. Sevoflurane is an excellent drug for inhalational induction in pediatric patients.
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Randomized Controlled Trial Comparative Study Clinical Trial
Does monitoring end-tidal isoflurane concentration improve titration during general anesthesia?
To assess the value of end-tidal anesthetic gas monitoring with respect to intraoperative hemodynamic stability and recovery times. ⋯ This study suggests that end-tidal isoflurane monitoring does not improve the titration of isoflurane during general anesthesia.
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Randomized Controlled Trial Comparative Study Clinical Trial
Antiemetic efficacy of a droperidol-morphine combination in patient-controlled analgesia.
To evaluate the antiemetic effectiveness and side effects of adding low-dose droperidol to morphine delivered via a patient-controlled analgesia (PCA) device. ⋯ An intermittent intake of low-dose droperidol with morphine given via a PCA delivery system in two treatment groups gave evidence for a dose-response relation between the amount of droperidol added and the proportion of patients needing a rescue antiemetic. The same result applied to the proportion of patients having an emetic episode and the number of times a rescue antiemetic had to be administered. There was no evidence that the low dose of droperidol added to morphine delivered via a PCA device increased unwanted side effects.
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Randomized Controlled Trial Comparative Study Clinical Trial
Hemodynamic effects during induction, laryngoscopy, and intubation with eltanolone (5 beta-pregnanolone) or propofol. A study in ASA I and II patients.
To evaluate the cardiovascular changes following induction of anesthesia, laryngoscopy, and intubation in patients receiving a bolus dose of either eltanolone or propofol. ⋯ Patients receiving either eltanolone or propofol showed similar cardiovascular changes to induction of anesthesia, although there were greater increases in arterial pressure and HR in those patients receiving eltanolone.