Journal of clinical anesthesia
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Randomized Controlled Trial Clinical Trial
The efficacy of intramuscular ketorolac in combination with intravenous PCA morphine for postoperative pain relief.
To examine the efficacy of intramuscular (IM) ketorolac used in combination with intravenous (IV) patient-controlled analgesia (PCA) morphine for postoperative pain relief following intra-abdominal gynecologic surgery. ⋯ IM ketorolac significantly decreased PCA morphine requirements. The analgesic effects of the two drugs appear to be additive.
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Randomized Controlled Trial Clinical Trial
Fentanyl-induced muscle rigidity as affected by pretreatment with amantadine hydrochloride.
To determine whether the degree of muscle rigidity in humans caused by the administration of high-dose fentanyl is affected by pretreatment with amantadine hydrochloride, a drug that stimulates the release of dopamine in the basal ganglia. ⋯ Muscle rigidity associated with the administration of high-dose fentanyl is not attenuated by prior administration of amantadine in the dose range studied.
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Randomized Controlled Trial Clinical Trial
Lidocaine blood levels following aerosolization and intravenous administration.
To determine whether, following aerosolization of lidocaine for topical airway anesthesia, intravenous (IV) lidocaine produces toxic lidocaine blood concentrations. ⋯ IV lidocaine can be safely administered following aerosolization of lidocaine in spontaneously breathing patients without producing toxic blood lidocaine concentrations.
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Randomized Controlled Trial Clinical Trial
Epidural opioids during laminectomy surgery for postoperative pain.
To determine whether morphine applied directly to the dura during laminectomy surgery provides superior postoperative analgesia during the first 24 hours. ⋯ Morphine 3 mg applied topically to the dura at the end of laminectomy surgery is a simple, safe, and effective way of providing improved postoperative analgesia.
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Randomized Controlled Trial Clinical Trial
Alkalinization of mepivacaine does not alter onset of caudal anesthesia.
To determine the effect of alkalinization of mepivacaine on onset of caudal anesthesia. ⋯ Alkalinization of mepivacaine does not significantly accelerate the onset of caudal anesthesia.