Journal of clinical anesthesia
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General anesthesia may lead in patients to unexpected and adverse reactions including toxicity. Glutathione S-transferases (GSTs) are enzymes responsible for the detoxification process of anesthetic agents. ⋯ The biochemical function and specific properties of GST render it a prognostic biomarker. This review demonstrates that GST can be valuable and promising toxicity indicator in patients undergoing general anesthesia.
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Review Meta Analysis
Dexamethasone for the prevention of postoperative sore throat: a systematic review and meta-analysis.
Intraoperative dexamethasone reduces the incidence of postoperative sore throat for up to 24 hours and postoperative hoarseness for 1 hour.
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Review Meta Analysis
Postoperative complications in patients with obstructive sleep apnea: a meta-analysis.
To determine whether a diagnosis of obstructive sleep apnea (OSA) imparts an increased risk of postoperative respiratory failure, cardiac events, and intensive care unit (ICU) transfer than patients with no OSA diagnosis. ⋯ Surgical patients with OSA are at increased risk of postoperative respiratory failure, cardiac events, and ICU transfer.
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To perform a prospective audit of the modified guideline for the management postdural puncture headache (PDPH) and present the results at 6 months. ⋯ Greater occipital nerve block with dexamethasone may have a role in the management of patients presenting with PDPH, who have failed conservative management. We present the results of our prospective audit and review the literature on GONB in the management of PDPH.
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Contemporary data suggest that approximately 18% of patients undergoing surgery will develop a major postoperative complication, and 3% to 5% will die prior to hospital discharge. Patients who develop a postoperative complication are at an increased risk of long-term mortality. Multiple studies have shown that perioperative hemodynamic optimization reduces the risk of postoperative complications and death in elective noncardiac surgical patients.