Current opinion in anaesthesiology
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Pharmacology is one of the corner stones of anesthesia. Outcome of anesthesia is related, in part, to both pharmacodynamics and pharmacokinetics of anesthetic drugs. Recent developments have indicated that among individuals, major differences exist in pharmacological effects. In this regard, sex, age, and genetic profile are increasingly considered to be of importance. ⋯ In the future, it is expected that an individual's pharmacological needs will be based on age, sex, and genomics.
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Curr Opin Anaesthesiol · Aug 2008
ReviewRecent advancements in the treatment of lumbar radicular pain.
Lumbar radicular pain is a common and often difficult condition to treat. Current literature supports the theory that radicular pain is at least in part due to an inflammatory process involving cytokines, including tumor necrosis factor alpha and interleukins. This review summarizes some of the most recent research concerning the use of tumor necrosis factor alpha antagonists and interleukin receptor antagonists in the treatment of lumbar radicular pain. ⋯ Treatment for lumbar radicular pain has long included epidural steroids to inhibit the inflammatory component of radicular pain. Recent studies have more precisely identified the cytokines responsible for this inflammatory process and indicate that inhibition of these cytokines may offer more specific and effective treatment for lumbar radicular pain.
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To evaluate the risks and safety of anaesthesia performed outside the operating room. ⋯ There is an urgent need for good data on complications with anaesthesia outside the operating room.
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Diagnostic and therapeutic endovascular stenting tended to expand in the last decade. The anesthetist may be asked to participate in the management of these patients with severe associated comorbidities complicating the delivery of anesthesia. This review describes current vascular stentings performed in the radiology suite and their relevant consequences interesting the anesthetist. ⋯ Literature review provides little information about anesthetic management of extracranial endovascular stentings. Knowledge of indication and consequences is mandatory for anesthetists in charge of these patients.