Journal of internal medicine
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the incidence of cardiovascular disease has declined rapidly in Sweden since the 1980s. We explored changes in major cardiovascular risk factors in northern Sweden between 1986 and 2009. ⋯ significant improvements were observed in major cardiovascular risk factors in northern Sweden between 1986 and 2009.
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Editorial Comment
Implementing chronic disease prevention amongst cancer survivors.
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An expanding spectrum of acute and chronic inflammatory diseases is considered 'autoinflammatory' diseases. This review considers autoinflammatory diseases as being distinct from 'autoimmune' diseases. ⋯ In contrast, autoinflammatory diseases are uniquely attributed to a dysfunctional monocyte caspase 1 activity and secretion of IL-1β; indeed, blocking IL-1β results in a rapid and sustained reduction in the severity of most autoinflammatory diseases. Flares of gout, type 2 diabetes, heart failure and smouldering multiple myeloma are examples of seemingly unrelated diseases, which are uniquely responsive to IL 1β neutralization.
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Multiple imputation (MI) is an advanced, principled method of dealing with missing data in statistical analyses, a common problem in medical research. This paper sought to document the use of MI in general medical journals and to evaluate the information provided to readers about the application of the procedure in studies. ⋯ Whilst still relatively uncommon, the use of MI has risen substantially, particularly in trials. MI is rarely adequately reported, leading to doubt about its appropriateness in some cases. This gives rise to uncertainty about conclusions reached and poses a barrier to attempts to replicate analyses. Guidelines for the reporting of MI should be developed.