Journal of internal medicine
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Multicenter Study Observational Study
Early standardized clinical judgement for syncope diagnosis in the emergency department.
The diagnosis of cardiac syncope remains a challenge in the emergency department (ED). ⋯ ESCJ including a standardized syncope-specific CRF has very high diagnostic accuracy and outperforms the EGSYS score, hs-cTnI and BNP.
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Multicenter Study
Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 COVID-19 patients.
To investigate prevalence and recovery of olfactory dysfunction (OD) in COVID-19 patients according to the disease severity. ⋯ OD is more prevalent in mild COVID-19 forms than in moderate-to-critical forms. OD disappeared in 95% of patients regarding objective olfactory evaluations at 6 months.
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Case Reports Multicenter Study
Clinical Features of Patients who had two COVID-19 Episodes: A European Multicenter Case-series.
To investigate the clinical features of patients who had two demonstrated coronavirus disease 2019 (COVID-19) episodes. ⋯ The recurrence of COVID-19 symptoms is associated with a similar clinical picture than the first episode in patients with initial mild-to-moderate COVID episode. The pathophysiological mechanisms underlying the development of second episode remain uncertain and may involve either true reinfection or virus reactivation from sanctuaries.
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Letter Multicenter Study Observational Study
Cholestatic liver injury in COVID-19 is a rare and distinct entity and is associated with increased mortality.
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Multicenter Study Observational Study
Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14,176 individuals.
Mitochondria play an important role in cellular metabolism, and their dysfunction is postulated to be involved in metabolic disturbances. Mitochondrial DNA is present in multiple copies per cell. The quantification of mitochondrial DNA copy number (mtDNA-CN) might be used to assess mitochondrial dysfunction. ⋯ Our data show an inverse association of mtDNA-CN with higher risk of metabolic syndrome and type 2 diabetes. A major part of the total effect of mtDNA-CN on type 2 diabetes is mediated by obesity parameters.