Annals of medicine
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Intestinal barrier dysfunction and systemic inflammation are common in obstructive sleep apnoea (OSA). We aimed to investigate the role of melatonin, an anti-inflammatory mediator, in mediating the relationships between OSA, intestinal barrier dysfunction and systemic inflammation. ⋯ Our study revealed that melatonin may be involved in mediating intestinal barrier dysfunction and systemic inflammation in moderate-to-severe OSA patients.
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Amphiregulin (AREG) is a growth factor linked to cardioprotection and heart pathology during myocardial stress. Our aim was to investigate cardiac AREG expression, its potential as a postmortem hypothermia marker and its possible stress hormone dependency in different types of deaths. ⋯ Severe hypothermia activates cardiac AREG expression practicable as a postmortem hypothermia marker. Cortisol and catecholamines may act as transcriptional modifiers of this gene, especially in long-term ischaemic heart disease. However, the exact role of these hormones in upregulation of AREG during hypothermia remains unclear.
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JEMS® (Joanne Elphinston Movement Systems) described as a systematic, holistic approach to analyze and create sound foundations for movement, is increasing in popularity among physiotherapists. The aim of this study was to investigate and capture the experiences and narratives of physiotherapists (PTs) using JEMS® for rehabilitation with patients in primary healthcare. ⋯ The FGD was chosen to capture the variety and width of experiences of the PTs using JEMS®. The opportunity for learning and reflecting in the FGDs was appreciated by the PTs. The interaction between the patient and the PT was described as fundamental in establishing foundations for movement. Opportunities to meet and treat patients regardless of functional limitations elaborated and were in that way applicable in primary healthcare where patients seek a physiotherapist for a variety of reasons.