Urology
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To establish a new animal model to mimic the clinical condition of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). CP/CPPS is a highly prevalent condition with detrimental effect on the quality of life, but the etiology, pathogenesis, and optimal treatment of CP/CPPS remain unknown. This new animal model would greatly contribute to the understanding and treatment of CP/CPPS. ⋯ Prostate extract with aluminum hydroxide injection could successfully induce CP/CPPS in Wistar rats, which was in a dose-dependent and injection number-dependent fashion. This animal model might greatly benefit with further understanding of the etiology, pathogenesis, and optimal treatment of CP/CPPS.
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To compare simultaneous and 2-stage surgical implantation of an artificial urinary sphincter (AUS) and penile prosthesis (PP) for patients with severe urinary incontinence and erectile dysfunction after prostatectomy. ⋯ AUS and PP synchronous placement is feasible and safe and as effective as the 2-stage procedure, with better acceptance by patients.
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Randomized Controlled Trial Multicenter Study Comparative Study
Preliminary assessment of safety and efficacy in proof-of-concept, randomized clinical trial of tanezumab for chronic prostatitis/chronic pelvic pain syndrome.
To assess the efficacy and safety of tanezumab, a humanized monoclonal antibody directed against the pain-mediating neurotrophin, nerve growth factor, to treat pain and other symptoms of chronic prostatitis/chronic pelvic pain syndrome in a Phase IIa, proof-of-concept clinical trial powered to provide 2-sided 90% confidence interval around the primary endpoint. ⋯ Tanezumab might improve symptoms for some patients with chronic prostatitis/chronic pelvic pain syndrome. Although proof of concept was not demonstrated in the present study, additional studies with larger populations and stricter inclusion criteria according to patient phenotype might identify populations in which antinerve growth factor treatment will provide clinical benefit.
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Comparative Study
Factors affecting renal function after open partial nephrectomy-a comparison of clampless and clamped warm ischemic technique.
To analyze factors impacting postoperative renal function after open partial nephrectomy using both the clampless and clamped warm-ischemic technique. ⋯ Body mass index and RENAL score were factors predictive of development of de novo estimated glomerular filtration rate <60 after partial nephrectomy, with increasing warm ischemia time also being predictive in clamped partial nephrectomy patients. Further investigation and long-term functional data are requisite.