Burns : journal of the International Society for Burn Injuries
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A high number of self-burning injuries are noted in Batticaloa. The epidemiology, outcome and psychosocial aspects of 87 patients admitted with such burns over a 2-year-period was studied. The patients were compared with accidental burns and patients using other methods of suicide. ⋯ In contrast, poison suicide records showed a male predominance and a gross under-representation of Muslims. Fire is a very significant method of suicide in our area. Social make-up and poor problem-solving ability may be contributing factors.
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In our earlier study metronidazole, administered orally, promoted healing in partial thickness burn wounds. This prompted us to hypothesize that metronidazole might have influenced lipid peroxidation, since increased levels of lipid peroxide are seen in burn injuries. Thus, the present study was aimed at investigating if metronidazole had any antioxidant action in burned rats. ⋯ They also significantly hastened the epithelization process. The results suggest a line between ends of oxidative products and rate of epithelization. Metronidazole, if administered to patients with burns, besides offering protection against anaerobic infections, might also protect the patients from some aspects of burn induced oxidative stress.
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To investigate the change of myocardial mitochondrial Ca(2+) transport and its mechanism in the early stage after burns. ⋯ Increase of [Ca(2+)](c) led to reinforcement of mitochondrial Ca(2+) uptake at the beginning of the post-burns period. ATP depletion and MP collapse cause myocardial mitochondrial Ca(2+) transport disorder in the following stages.
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Major incidents require careful planning if they are to be managed well. Although a generic plan to deal with all major incidents is essential, a number of "special incidents" deserve special consideration because of their potential to impact on specialist services. This paper examines the problems of managing a major incident involving large numbers of burns casualties. ⋯ Specific consideration should be given to the problems of managing a major incident involving burns casualties.
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Animal models of burn injury indicate oxygen radicals as causative agents in the local wound response, as well as in the development of burn shock and distant organ injury. This study was designed to determine the possible protective effect of melatonin treatment against oxidative damage in the liver, lung and intestine induced by burn injury. Under ether anaesthesia, the shaved dorsum of rats was exposed to a 90 degrees C bath for 10s to induce burn injury. ⋯ Liver, lung and intestine tissues were taken for the determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity and protein oxidation (PO). Severe skin scald injury (30% of total body surface area) caused a significant decrease in GSH level, significant increases in MDA and PO levels, and MPO activity at postburn 3 and 24h. Treatment of rats with melatonin (10mg/kg) significantly elevated the reduced GSH levels while it decreased MDA and PO levels as well as MPO activity.