Burns : journal of the International Society for Burn Injuries
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External fixators designed specifically for severe, late postburn contractures of hand and wrist have been used in five patients between 1993 and 1997 with follow up for an average of 30.2 months. The mean age of patients at operation was 16.6 years ranging from 14 to 20 years. They had a number of failed operations. ⋯ After reconstructive operations, at least one hand function was attained. We have found the external fixator method to be helpful in treating severe, fixed and complex postburn contractures of hand where previous surgery had failed. This study indicates the uses and benefits of external fixators as a soft tissue lengthener when correcting progressively complex burn contractures of hand.
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Letter Case Reports
Compartment syndrome: effect of limb position on pressure measurement.
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In this study, we investigated the effect of inflammatory cytokines on matrix metalloproteinase (MMP-1) and TIMP-1 production in human dermal fibroblasts, which play a pivotal role in wound healing, ranging from the synthesis and remodeling of extracellular matrix (ECM) to the synthesis of growth factors. The balance of MMPs and TIMPs is crucial in directing successful wound repair. Human adult dermal fibroblasts were seeded in six well plates (7.5 x 10(4) cells/ml) in complete media. ⋯ However, TNF-alpha significantly increases TIMP-1 protein levels. Data suggests differential regulation of MMP-1 and TIMP-1 protein levels by the cytokines found in stimulated dermal fibroblasts. Further characterization of this response will provide an understanding of the mechanisms of pathogenesis of extracellular matrix (ECM) and the potential role of metalloproteinases in tissue remodeling after injury.
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Burn injuries require a multidisciplinary approach. Emergency Departments can play vital roles in the treatment of burns. The purpose of this study is to investigate the epidemiological and clinical characteristics of the adult burn patients admitted to our Emergency Department and to determine the frequency of the patients who were treated on an outpatient basis and discharged from the Emergency Department. ⋯ Burns were mostly due to accidents arising from carelessness, ignorance, hazardous traditions and improperly manufactured products. These can be prevented through mass education programs countrywide. Because almost all burn patients present to Emergency Departments first and not all hospitals can employ burn specialists, the patients with minor burns can be treated on an outpatient basis and the treatment of severe burns can be effectively initiated by emergency physicians.