Burns : journal of the International Society for Burn Injuries
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It is well known that induction of immunotolerance with allogeneic skin transplantation is generally difficult. This study attempted to find an immunosuppressive protocol for skin allograft rejection involving interleukin-16 (IL-16) and interleukin-10 (IL-10), because both are known to inhibit mixed lymphocyte reaction (MLR). ⋯ IL-16-cDNA- and IL-10-cDNA-double-transfected squamous cell carcinoma cell line were used as an in vitro model and they produced more than 20 ng/ml of IL-16 and 100 pg/ml of IL-10 in the supernatant, which significantly inhibited MLR and also the activation of allogeneic lymphocytes, which were stimulated directly by allogeneic double-cDNA-transfectant cells. Thus allogeneic skin graft producing IL-16 and IL-10 might have a local immunosuppressive action that could prolong graft survival.
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This study enrolled 22 participants with hypertrophic scarring after burn who received treatment with co-transplantation of acellular dermal matrix and epidermis of either normal skin or scar tissue. Scar thickness was evaluated with high frequency ultrasonography and the distribution of keratinocyte stem cells was detected by immunostaining. The results showed p63-positive keratinocyte stem cells throughout the epidermis of scar tissue. However, if co-transplanted on acellular dermal matrix, this effectively inhibited scar formation and pruritus, providing an alternative method to treat hypertrophic scarring.
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This retrospective review of data from a single burn centre revealed a sharp decrease in the mortality associated with childhood burn. Between January 1998 and January 2006, 1035 children were admitted to our burn unit in Ankara. The overall mortality was 5.8%, falling from 23% between 1998 and 2000 to 5.6% between 2001 and 2005. ⋯ Electrical burns remained a major health problem with significant amputation rates and lengths of hospital stay. Candidaemia was a mortal consequence of burn. Renovation of the unit with changes in the management of burn victims from conservative treatment to more up-to-date approaches were associated with improved outcomes.
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The aim of this study was to evaluate the effect of an anti-flagellin sub-type monoclonal antibody (anti-fla-a) on Pseudomonas aeruginosa infection in a mouse burn model and to assay bacterial dissemination and invasiveness. ⋯ Anti-fla-a is effective in reducing mortality and morbidity in murine P. aeruginosa-infected burn model.