Burns : journal of the International Society for Burn Injuries
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Burns are associated with immune suppression and subsequent development of sepsis. Dendritic cells (DCs) are potent antigen-presenting cells that serve as a critical link between the innate and acquired immune systems, and are essential in coordinating the host response to pathogens. ⋯ Analysis revealed significant reductions in circulating mDCs and pDCs in survivor as well as non-survivor septic cases compared with non-septic cases and controls (p<0.001). These findings suggest that deficiencies in mDCs and pDC subsets are related to sepsis following severe burn, and may contribute to immunosuppression among burn victims.
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To investigate demographic risk factors for self-immolation patients. ⋯ This study suggests that being the first or last child of a family might be a risk factor for self-immolation. For married persons, having children might serve as a protective factor from self-immolation. Other variables such as family size, marital status, number of children, BMI, employment state, educational status, early school drop-out, and parent/guardian employment status did not play a role as individually protective or risk factors for self-immolation.
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Organ protection is a routine therapy in severe burn/scald injuries, and damage following early scald injury was not been fully elucidated. Our aim was to verify the beneficial effects of ulinastatin on pancreatic and renal damage associated with scald injury. Lewis rats were subjected to 30% total body surface area (TBSA) scald injury, and were randomly divided into a burn control (S group) and an ulinastatin-treated group (U group). ⋯ From 24 to 72 h, in comparison with the U group, higher levels of BUN, Scr and serum amylase were observed in the S group which were all lower than the common upper limits. Our results demonstrated that pancreatic and renal damage associated with autoimmunity and oxidant attack occurred after severe scald. Ulinastatin exhibits significant protective effects on these effects.