Burns : journal of the International Society for Burn Injuries
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This study presents a 26-year epidemiological assessment of burn injury hospitalisations for people 15-29 years of age in Western Australia. ⋯ Downward trends in burn injury hospitalisations for both males and females 15-29 years of age were observed; however, males and Aboriginal persons have significantly elevated hospitalisation rates.
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To discuss the effect of Poloxamer 188 (P188) on deepening of deep second-degree burn wounds in the early stage after burn. ⋯ Systemic application of P188 on deep second-degree burn wounds at the early stage may alleviate wound deepening, whose mechanism may be related to timely sealing up the damaged cell membrane and inhibiting the inflammatory reaction.
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Organ protection is a routine therapeutic application to severe burn/scald injuries, and organic damage following early scald injury is not absolutely elucidated. Our aim is to verify the good effects of Ligustrazine on pancreatic and renal damage associated with early scald injury. A total of 120 Lewis rats subjected to 30% total body surface area (TBSA) scald injury, were randomly divided into simple scald group (S group) and Ligustrazine treated group (L group). ⋯ From 24 to 72 h, in comparison with the L group, higher levels of BUN, Scr and serum amylase were observered in the S group, which were also higher than the common upper limits. Therefore, our results demonstrated potential pancreatic and renal damage associated with autoimmunity and oxidant attack occurred following early scald injury. Ligustrazine exhibits significant protective effects.
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The aim of this study was to examine whether administration of valproic acid (VPA) improves blood circulation and survival after lethal burn shock. Forty adult male Beagle dogs underwent a 50% TBSA full-thickness flame injury. In the first 24 h after burn, animals were randomly divided into four groups: NR group received no treatment. ⋯ Survival at 72 h after burn was in following order: VR (100%)>VPA (60%)>2M2P (30%)>NR (10%). Our results showed that histone deacetylace inhibitor (HDACI) valproic acid significantly improved hemodynamics, intestinal perfusion, and the survival rate after lethal burn shock. The mechanism may be attributable partly to the lowering of the level of proinflammatory factors, ameriolation of vasopermeability-induced visceral edema, reduction of blood volume loss, and protection of vital organs through inhibition of histone deacetylase activity of cell of vital organs.