Burns : journal of the International Society for Burn Injuries
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Burn is associated with severe immune dysfunction, including an anti-inflammatory state that occurs late after burn. While increased nitric oxide (NO) production is associated with severe infection and sepsis, the effect of burn trauma on these levels during a non-lethal infection remains unknown. We hypothesized that in a mouse model, (1) NO levels would be increased after infection without trauma and (2) burn would lead to decreased NO production even during infection. ⋯ While increases in NO are expected over the course of an infection without prior trauma, burn and subsequent immune suppression decreases NO levels even in the presence of infection.
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To describe patterns in thermal injury incidence and hospitalisations by age, gender, calendar year and socioeconomic status among 0-4 year olds in England for the period 1998-2013. ⋯ Incidence of all thermal injuries and those hospitalised for ≥72h reduced over time. Steep socioeconomic gradients support continued targeting of preventative interventions to those living in the most deprived areas.
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San Juan (Summer Solstice) is an annual festival celebrated in many parts of Spain on June 24 by lighting bonfires on beaches and in open air. The aim of this study is to analyse the patient profile of those sustaining burns the night before San Juan. ⋯ The results of this study can guide prevention campaigns during these festivities in the future.
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The aim of our study was to investigate the effect of lentinan on regulatory T cells (Tregs) in sepsis, especially on the generation of interleukin (IL)-10 via regulation of Erk-FoxO1 signaling. ⋯ Lentinan may improve the outcome of postburn sepsis by suppressing LPS-triggered Erk-FoxO1 activation. Consequently, the hyperfunction of CD4(+) CD25(+) Tregs is inhibited, leading to a shift in the inflammatory status from Th2 to Th1 in postburn sepsis.