Burns : journal of the International Society for Burn Injuries
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Observational Study
Cross-cultural validation of the Itch Man Scale in pediatric burn survivors in a South African setting.
Pruritus or itch is a common symptom after burn injuries. The Itch Man Scale has been recommended to assess itch severity in children. The aim of this prospective observational study was to perform a cross-cultural validation of the Itch Man Scale by comparing it with the Numeric Rating Scale (NRS) and the Toronto Pediatric Itch Scale. ⋯ We concluded that the Itch Man Scale has promising validity and is a user-friendly tool to use in clinical practice to determine the itch intensity in children younger than 13years in a South African setting.
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Comparative Study
Hypertonic saline resuscitation protects against kidney injury induced by severe burns in rats.
Proper fluid resuscitation can relieve visceral damage and improve survival in severely burned patients. This study compared the effectiveness of resuscitation with 400mEq/L hypertonic saline (HS) and sodium lactate Ringer's solution (LR) in rats with kidney injury caused by burn trauma. ⋯ The data indicate that 400mEq/L HS solution reduces hyponatremia and renal edema, inhibits the release of inflammatory mediators, and alleviates oxidative stress injury, thus protecting against kidney injury induced by severe burns.
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Randomized Controlled Trial
Evaluation of the analgesic effects of duloxetine in burn patients: An open-label randomized controlled trial.
To evaluate efficacy of addition of duloxetine to usual analgesic regimens in management of burn pain. ⋯ Addition of duloxetine may increase efficacy of the other analgesics in reduction of the burn pain.
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Social support and spirituality are important issues among burn survivors that appear to affect their posttraumatic growth (PTG). ⋯ The mediating role of spirituality should provide new visions for the augmentation of PTG in burn survivors.
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After similar extent of injury there is considerable variability in scarring between individuals, in part due to genetic factors. This study aimed to identify genetic variants associated with scar height and pliability after burn injury. An exome-wide array association study and gene pathway analysis were performed on a prospective cohort of 665 patients treated for burn injury. ⋯ Using this approach biological processes related to the nervous system and cell adhesion were the predominant gene pathways associated with both SH and SP. This study suggests genes associated with innervation may be important in scar fibrosis. Further studies using similar and larger datasets will be essential to validate these findings.