Burns : journal of the International Society for Burn Injuries
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Nitric oxide (NO) is an important mediator in numerous physiological and pathophysiological events. After thermal injury an increase in plasma and urinary levels has been observed. The real importance of this fact is unknown. ⋯ The authors suggest the possible role of NO determination as an indicator of sepsis. The role of NO synthesis inhibitors is discussed. Further studies are needed to clarify these questions.
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Comparative Study
Saving the zone of stasis in burns with recombinant tissue-type plasminogen activator (r-tPA): an experimental study in rats.
Hypercoagulability 2-3 h following scald injury and vessel thrombosis are well-known complications of burn injury. The present study was designed to determine the effect of recombinant tissue-type plasminogen activator (r-tPA) on vessels thrombosis in zones of stasis postburn. Twenty rats were assigned to experimental and control groups (N:10). ⋯ The percentage of live interspace and vertical space areas in the experimental group was 87.8 per cent on day 7, while it was 31.8 per cent in the control group (P<0.05). Dry/wet ratios did not reveal any significant difference at 24 h postburn. These results confirm that treatment with this selective fibrinolytic agent (r-tPA) after burn injury would have some benefits on saving the zone of stasis in burns.
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This is the first reported case of congenital skin loss following endoscopic placental laser coagulation, a new technique for the ante-natal treatment of twin-twin transfusion syndrome. The skin defect healed rapidly after birth with dressings alone, mimicking the spontaneous re-epithelialisation of a minor burn wound or aplasia cutis congenita.
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The aim of the study was to determine what the effect of a stressful work environment is on the psychosocial functioning of burn unit nurses. A standardised scale, the Psychosocial Functioning Inventory, was used to measure psychosocial functioning. In addition, a questionnaire was constructed to identify sources of stress, coping mechanisms and the need for support programmes. ⋯ Workload and poor remuneration were the most important stressors. Good relationships amongst the nurses and team support enabled them to cope with the stressors. It is recommended that attention be paid to remuneration of nurses, a better nurse-patient ratio and the promotion of interdisciplinary teamwork.
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Comparative Study
Contribution of the sensory and sympathetic nervous system to scalding-induced edema in the rat paw.
It has recently been hypothesized that both the sensory and sympathetic nervous system contribute to the inflammatory reaction. A scalding model was developed in anaesthetized rats to investigate the contribution of neuropeptides in heat-induced edema localized to the hindpaw. After immersing the paw in water at 60 degrees C for 10, 20, 30 and 60 s, edemic reactions were registered as change of paw volume in a plethysmograph and hindpaw perfusates collected to measure the content of neuropeptides by radioimmunoassay. ⋯ There was a significant decrease of edema formation in the scalded nerve ligated paw as compared with the scalded paw on the non-ligated side. Neurokinin A was not detected in nerve ligated rats before or after scalding, whereas mononeuropathic rats showed increased concentrations of neuropeptide Y. The present results indicate that the sensory as well as the sympathetic nervous system, possibly through the release of neuropeptides, may contribute to scald-induced edema.