Burns : journal of the International Society for Burn Injuries
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Randomized Controlled Trial Clinical Trial
A comparative study of silicone net dressing and paraffin gauze dressing in skin-grafted sites.
This prospective randomized study has compared paraffin gauze dressing (n = 19) with silicone net dressing (Mepitel, n = 19) applied as the first layer to newly grafted burn wounds. At the first postoperative dressing visual analogue pain scores were greater in the paraffin gauze group (mean 4.4) than in the silicone net group (mean 1.4, P < 0.01). ⋯ Dressings were harder to remove in the paraffin gauze group as assessed by a simple scoring system (P < 0.001). In conclusion silicone net dressing confers advantages over conventional paraffin gauze, especially in reducing patient discomfort during dressing changes.
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Comparative Study
Reduction of progressive burn injury by a stable prostaglandin I2 analogue, beraprost sodium (Procylin): an experimental study in rats.
Beraprost sodium is a chemically stable prostaglandin I2 analogue with antiplatelet and vasodilator actions. Burn injury causes thrombosis and vessel occlusion by increasing the blood viscosity and by thermal damage to the vascular network in the dermis. A vascular response also occurs in the uninjured dermis surrounding the site of injury. ⋯ Skin blood flow was measured with a laser Doppler flowmeter, and the development of oedema as well as the area of necrotic tissue were also determined. The extent of skin necrosis and oedema were significantly reduced in the beraprost sodium-treated rats, and blood flow in the zone of stasis was increased. These findings demonstrate that prostaglandin I2 plays an important role in burn injury and that beraprost sodium can reduce secondary necrosis in the zone of stasis.
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In a prospective study, data on 175 patients treated between June 1993 and February 1994 has been analysed. In this series, adolescents and young adults (11-40 years) comprised 79.4 per cent of the patients. ⋯ The overall mortality rate was 56.5 per cent, below 40 per cent surface area burned (%BSAB) it was 6.1 per cent and above 70 per cent it was 100 per cent. Flame burns resulted in maximum deaths (86.1 per cent). 40 per cent of the patients had more than 70 per cent BSAB burns in this series, which accounts for the high mortality.