Burns : journal of the International Society for Burn Injuries
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Dressings play a crucial role in the management of burn wounds. In this study, cotton bandages were modified with poly (N-isopropylacrylamide)/graphite oxide/nano silver (PNIPAM/GO-Ag) hydrogel to obtain a novel dressing (PNIPAM/GO-Ag/COT). The healing effect of the PNIPAM/GO-Ag/COT dressing on deep second-degree burn wounds in rats and the changes of related inflammatory factors were explored and analyzed systematically. ⋯ The results showed that, compared with the blank group (rats without the dressing treatment), the PNIPAM/GO-Ag/COT dressing reduced the expression of TNF-α by approximately 18 % and promoted the bFGF expression in wound tissue. Compared to the control group (rats with the gauze treatment), the wound healing rate in the PNIPAM/GO-Ag/COT dressing group was 58 % on the 14th day, with an increase of 30 %. These results demonstrated that the PNIPAM/GO-Ag/COT dressing primarily promoted burn wound healing by reducing inflammatory reactions, promoting collagen deposition, and enhancing the expression of bFGF.
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Clinically, the condition of skeletal muscle injury is the key to the process of high voltage electrical burn (HVEB) wound repair. The aim of this study was to identify the potential mechanisms and intervention targets of skeletal muscle injury after HVEB. ⋯ Skeletal muscle injury caused by HVEB is characterized by adjacent endangered tissue progression after injury. Ferroptosis is involved in the mechanism of HVEB, and iron metabolism-related proteins may be potential targets for preventing progressive skeletal muscle injury.
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The Abbreviated Burn Severity Index (ABSI) by Tobiasen, which is commonly used to estimate the mortality risk of severely burned patients, calculates an additional point for the existence of full-thickness (third-degree) burns. [1] However, the score does not consider the extent of the body surface affected by third-degree burns. To understand whether there is a way to improve ABSI prediction power, this study aims to determine the influence of full-thickness burns on survival rates and how it affects the predictive precision of the ABSI. ⋯ For patients with a TBSA < 20 %, the presence of full-thickness burns is not relevant for survival. In contrast to this observation, the percentage of full-thickness burns is of crucial prognostic importance for patients with a TBSA of > 20 %. By adjusting the ABSI and taking into account the exact percentage of third-degree burns, an improvement in the prognostic precision of the score could be achieved.
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This study aims to explore the potential of a scaffold composed of drug-chitosan-hydroxyapatite (HA) in improving tissue treatment. The focus of the investigation lies in analyzing the physical and biological properties of the scaffold and evaluating its mechanical characteristics through finite-element analysis. To synthesize microcapsules containing dextran-diclofenac sodium, the electrospraying method was employed. ⋯ The results indicated that the average size of the microcapsules was in the range of 170 to 180 µm, and the porosity of the prepared tissue was between 52 % and 61 %. The experimental compressive properties revealed that an increase in the volume fraction of the embedded microcapsules led to an increase in the maximum compressive stress and compressive modulus of the scaffolds by up to 54.95 % and 53.18 %, respectively, for the scaffold containing 20 % VF of pharmaceutical microcapsules compared to the specimen containing 10 % VF. In conclusion, the developed scaffold has the potential to serve as an effective wound dressing, with the ability to provide structural support, facilitate controlled drug release, and promote wound healing.