Burns : journal of the International Society for Burn Injuries
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It is the basic task of burn therapy to cover the wound with self-healthy skin timely and effectively. However, for patients with extensive burns, autologous skin is usually insufficient, and allogenic or heterogeneous skin leads to strong immune response. It is vital to choose an appropriate treatment for deep extensive burns. ⋯ Then BM-MSCs-seeded DADM (DADM/MSCs) was implanted into mice cutaneous wound, and the effect of DADM/MSCs dermal substitute was assessed on skin regeneration. As a result, BM-MSCs survived well and DADM/MSCs scaffolds significantly promoted wound healing in terms of angiogenesis, re-epithelialization and skin appendage regeneration. DADM/MSCs scaffold may represent an alternative promising therapy for wound healing in deep extensive burns.
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The quality of clinical data held in administrative databases is crucial for appropriate funding of health care services. As Diagnosis-Related Groups (DRGs) continue to play an important role in hospital payment mechanisms, proper coding of diagnoses and procedures is of most concern. This study used an administrative, nationwide Portuguese inpatient database to characterize and assess coding patterns in burn-related hospitalization data, with a special focus on identifying suspected miscoding practices that could be affecting APR-DRG (All-Patient Refined Diagnosis-Related Groups) classification. ⋯ Moreover, there seems to be a lack of standard in coding debridement procedures among the evaluated hospitals. Overall, we found some suspected coding patterns that could potentially be associated with miscoding practices impacting APR-DRG classification. Those findings could not only be relevant for planning future audit processes and improving medical coding practices, but also for discussing quality and desirable features of burn-related clinical data, keeping in mind their use for other purposes beyond DRG grouping, namely clinical and health care services research, as well as health care management.