Burns : journal of the International Society for Burn Injuries
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Randomized Controlled Trial Comparative Study Clinical Trial
A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine.
Histological and clinical studies of wound healing have been made on comparable fresh partial thickness burns with honey dressing or silver sulfadiazine (SSD) in two groups of 25 randomly allocated patients. Of the wounds treated with honey 84 per cent showed satisfactory epithelialization by the 7th day, and in 100 per cent of the patients by the 21st day. In wounds treated with silver sulfadiazine, epithelialization occurred by the 7th day in 72 per cent of the patients and in 84 per cent of patients by 21 days. ⋯ Fifty two per cent of the silver sulfadiazine treated wounds showed reparative activity with inflammatory changes by the 7th day. Reparative activity reached 100 per cent by 21 days with the honey dressing and 84 per cent with SSD. Thus in honey dressed wounds, early subsidence of acute inflammatory changes, better control of infection and quicker wound healing was observed while in the SSD treated wounds sustained inflammatory reaction was noted even on epithelialization.
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Randomized Controlled Trial Clinical Trial
The safety of topical anaesthetic and analgesic agents in a gel when used to provide pain relief at split skin donor sites.
Post operative pain from split skin donor sites is a recognised problem. This study was carried out to assess the safety of a 'depot' preparation of bupivacaine and ketoprofen when applied to denuded dermis of a split donor site. Two groups of six patients each received either bupivacaine gel (2.5 mg/ml) or ketoprofen gel (1.6 mg/ml). ⋯ Ketoprofen levels also peaked at 120 min and the mean level obtained was 0.20 microgram/ml (range 0.12-0.27). The reported toxic serum level for bupivacaine was 4 micrograms/ml and for ketoprofen is 1128 micrograms/ml. In conclusion, these preparations, when applied to denuded dermis of a split skin donor site, are unlikely to result in toxic levels.
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Randomized Controlled Trial Comparative Study Clinical Trial
Failure of therapeutic ultrasound in healing burn injuries.
Experimental observations suggest that therapeutic ultrasound stimulates wound healing. Despite the controversy concerning its efficiency, this procedure is commonly implemented. ⋯ No stimulating effect of ultrasound could be demonstrated in these two groups, monitored by histological examination and a size index. These results discourage the clinical administration of therapeutic ultrasound to enhance the healing of burns.
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Randomized Controlled Trial Clinical Trial
A comparative study of silicone net dressing and paraffin gauze dressing in skin-grafted sites.
This prospective randomized study has compared paraffin gauze dressing (n = 19) with silicone net dressing (Mepitel, n = 19) applied as the first layer to newly grafted burn wounds. At the first postoperative dressing visual analogue pain scores were greater in the paraffin gauze group (mean 4.4) than in the silicone net group (mean 1.4, P < 0.01). ⋯ Dressings were harder to remove in the paraffin gauze group as assessed by a simple scoring system (P < 0.001). In conclusion silicone net dressing confers advantages over conventional paraffin gauze, especially in reducing patient discomfort during dressing changes.
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Randomized Controlled Trial Clinical Trial
Topical ketorolac has no antinociceptive or anti-inflammatory effect in thermal injury.
This study investigated the antinociceptive and anti-inflammatory effect of a topical non-steroidal anti-inflammatory drug in human thermal injury. Twelve healthy unmedicated volunteers had identical burn injuries produced on the medial side of both calves with a 49 degrees C 15 x 25 mm thermode. ⋯ Burn injury led to a decrease in HPDT, HPT and MPDT, an increase in EI and development of mechanical hyperalgesia (P < 0.05). Ketorolac gel had no effect on any of the nociceptive or inflammatory variables studies (P > 0.2).