European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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Eur Arch Otorhinolaryngol · Aug 2003
Randomized Controlled Trial Comparative Study Clinical TrialRopivacaine compared to lidocaine for tonsillectomy under local anaesthesia.
The aim of the present study was to investigate the safety and efficacy of ropivacaine compared to lidocaine for tonsillectomy under local anaesthesia. During the last 2 years, 77 patients undergoing tonsillectomy under local anaesthesia in the seated position were randomised to receive ropivacaine or lidocaine. The following parameters were recorded: time to surgical anaesthesia, the duration of the procedure, postoperative pain, the need for analgesics during the first 10 h after surgery, cardiac arrhythmias, the occurrence of allergic reaction and larynx spasm. ⋯ Adjuvant analgetics were administered later and in significantly lower doses in the ropivacaine patients. There were no adverse reactions. In conclusion, ropivacaine in local tonsillectomy is safe, has a longer onset-time, but is more efficient concerning postoperative pain than lidocaine.
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Eur Arch Otorhinolaryngol · Feb 2003
Randomized Controlled Trial Multicenter Study Clinical TrialBetahistine dihydrochloride in the treatment of peripheral vestibular vertigo.
The present study compares the efficacy and safety of betahistine dihydrochloride to that of a placebo in recurrent vertigo resulting from Meniere's disease (MD) or in paroxysmal positional vertigo (PPV) of probable vascular origin. The design was double-blind, multicentre and parallel-group randomised. Eleven Italian centres enrolled 144 patients: 75 of the patients were treated with betahistine (41 MD/34 PPV) and 69 with placebos (40 MD/29 PPV). ⋯ Associated symptoms and the quality of life also were significantly improved by betahistine. Both the physician's judgement and the patient's opinion on the efficacy and acceptability of the treatment were in agreement as to the superiority of betahistine. The effective and safe profile of betahistine in the treatment of vertigo due to peripheral vestibular disorders was confirmed.