European journal of internal medicine
-
Eur. J. Intern. Med. · Jan 2020
Review Meta AnalysisNatriuretic peptides in acute kidney injury - A sojourn on parallel tracks?
The focus of this review was to elicit the mechanistic logic of the experimental and clinical study designs of natriuretic peptides (NP) in acute kidney injury (AKI) and to understand their respective outcomes. ⋯ Reasons for the divergence of experimental and clinical outcomes of NPs in AKI are discussed in this review article.
-
Eur. J. Intern. Med. · Jan 2020
ReviewComorbidities in chronic heart failure: An update from Italian Society of Cardiology (SIC) Working Group on Heart Failure.
The increasing number of patients with heart failure HF and comorbidities is due to aging population and increase of life expectancy of patients with cardiovascular disease. Encouraging results derived by recent trials may suggest some comorbidities as new targets for new drugs, highlighting the need for a better understanding of the comorbidities' effects in HF patients and the need of a multidisciplinary approach for the management of chronic HF with comorbidities. We report a brief review about main cardiovascular and non-cardiovascular comorbidities in HF patients in order to update physicians and researchers engaged in the HF research or in "fight against heart failure."
-
Eur. J. Intern. Med. · Jan 2020
ReviewPractical use of Direct Oral Anti Coagulants (DOACs) in the older persons with atrial fibrillation.
Direct Oral Anticoagulants (DOACs) consistently demonstrated a greater net clinical benefit compared to Vitamin K Antagonists (VKAs) also in persons aged 75 years and over, who account for the largest proportion of AF patients; however, major uncertainties in DOACs prescription have to do with this age group. In this review, persistent uncertainties and implications of frailty and geriatric syndromes on DOACs prescription, and practical use of DOACs in real-world older persons, and will be discussed.
-
Eur. J. Intern. Med. · Jan 2020
Renal function and delirium in older fracture patients: different information from different formulas?
the association between renal function and delirium has not been investigated in older fracture patients. Creatinine is frequently low in these subjects, which may influence the association between delirium and renal function as estimated with creatinine-based formulas. Cystatin C could be a more reliable filtration marker in these patients. ⋯ in older fracture patients, moderate renal impairment was independently associated with delirium only among subjects aged 75-84, when eGFR was estimated with cystatin-based or BIS 1 equations, and not with the most commonly used equations (MDRD, CKD-EPIcr).