European journal of internal medicine
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Eur. J. Intern. Med. · May 2020
Meta AnalysisAssessing the association between fluoroquinolones and emerging adverse drug reactions raised by regulatory agencies: An umbrella review.
Regulatory agencies warned against fluoroquinolones for the management of minor infections because of the risk of emerging adverse events (collagen-associated adverse events, neuropsychiatric toxicity and long-term disability). We aimed to assess quality and credibility of evidence as well as causality regarding these putative associations. ⋯ Our analysis supports credible, plausible and highly suggestive associations with AAD (rare occurrence but strong causality) and ATD. Limitations of both umbrella reviews and observational evidence should be considered.